[The effect of mefenamic acid on the immunity indices and hemostatic system in cancer patients and on the cathepsin D-like protease activity in the tissues in cancer of the large intestine]. / Vliianie mefenaminovoi kisloty na pokazateli immuniteta, sistemu gemostaza onkologicheskikh bol'nykh i na aktivnost' proteazy, podobnoi katepsinu D, v tkani raka tolstoi kishki.

The study of the effect of sodium mefenaminate on radiation resistance of rats yielded positive results. Clinical investigations showed mefenamic acid to decrease the activity of cathepsin D-like protease in colonic cancer tissue. The acid failed to affect the proteolytic activity of the normal mucosa. It revealed an immunomodulating activity and influenced the hemostatic system which usually manifested itself in amelioration of hypercoagulation.

[Plasmapheresis in combined measures to prevent postoperative thromboembolic complications in cancer patients]. / Plazmaferez v komplekse meropriiatii po profilaktike posleoperatsionnykh tromboémbolicheskikh oslozhnenii u onkologicheskikh bol'nykh.

Plasmapheresis with exfusion of 30-60% circulating plasma volume has been first used in combination with conventional drug therapy for the prevention of postoperative thromboembolic complications in cancer patients at risk of thrombosis (II-III stage lung cancer). The use of plasmapheresis made it possible to reduce the incidence of postoperative thromboembolic complications by 40.6% and to decrease postoperative lethality.

[The effect of plasmapheresis on hemostasis in lung cancer patients]. / Vliianie plazmafereza na gemostaz bol'nykh rakom legkogo.

To correct hemostasis, 32 patients with lung carcinoma underwent plasmapheresis with exfusion of 50% the circulating plasma volume one day before surgery. Plasmapheresis was coupled with the conventional drug therapy. As compared with the control group patients (n-32) who did not receive plasmapheresis, the main group patients demonstrated that the use of the multimodality correcting therapy made all the components of hemostasis return to normal and minimized the rate of postoperative thromboembolic complications by 40.6% and the postoperative lethality by 18.7%.

[Mechanism of formation of blocking factors and method of antiblocking immunotherapy in malignant tumors]. / O mekhanizme obrazovaniia blokiruiushchikh faktorov i metode antiblokiruiushchei immunoterapil zlokachestvennykh opukholei.

A hypothesis on blocking factor formation in carcinogenesis is discussed. Destabilisation of cell membranes and increased levels of proteolytic enzymes in tumor tissue are considered to be the trigger mechanism. Protease level in large bowel tumor was found to be higher than in normal tissue. Plasminogen level in cancer patients was significantly higher than in healthy subjects. Application of different experimental schemes of treatment with membrane-stabilizing drugs and an inhibitor of protease was followed by antitumor and antiblocking effects. Sorption of rheumatoid factor and immune complexes from plasma led to a decrease in the blocking activity of plasma in vitro. In cases of rectal cancer, plasmapheresis was followed by tumor regression and a fall in immune complex concentration.

[Immunologic reactivity in different courses of stomach cancer]. / Sostoianie immunologicheskoi reaktivnosti pri razlichnom techenii zabolevaniia rakom zheludka.

The immunological status was examined in 106 patients with cancer of the stomach, who were subjected to different operative interventions. 74 of them were considered to be operable and 32-inoperable. The immunological activity was compared (according to the tests of cell immunity and general immunological reactivity) in aggressive--unfavourable and torpid-favourable course of the disease. A torpid course of the lesion after surgery for gastric cancer was associated with stabilization and some activation of immune response indices. However, radical operations fail to provide the normalization of these tests, and the state of immune depression in the patients would persist. An aggressive course of the lesion after surgery for gastric cancer was associated with considerable shifts in immunological tests indices toward their suppression, these being increased with the approach of patient's death.